Having the valve hole centred on the profile on asymmetrical rims, constitutes a problem for Tubeless tires use?

On Tubeless Ready rims, it is usual to have the valve hole centred on the profile, and so it is located on a profile edge so that the user can choose which system to use (tubeless or inner tube). Despite this situation, it will never be a problem to use Tubeless tires.

The important is to guarantee that the valve is well-sealed on the tire! (See the previous topic).